Overview

Introduction to the Disease

Herpes zoster (shingles) presents as a painful vesicular rash and is caused by reactivation of the varicella-zoster virus within the dorsal root or cranial nerve ganglia1. Post herpetic neuralgia is the most common complication of herpes zoster and is one of the most intractable painful disorders. Herpes is a very common skin disease caused by HSV that can affect mouth (oral) and/or the area around the penis or vagina (genital), upper thighs or buttocks.

Virus VZV and HSV are widespread human pathogens, with about 60 to 90% of the population latently infected by both viruses by adulthood. In India, >30% of persons >15 years of age are susceptible for VZV infections.

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Solution

Indications and Effects of Penvir

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Herpes zoster is viral infection that occurs with reactivation of the varicella-zoster virus. It is usually a painful but self-limited dermatomal rash. Symptoms typically start with pain along the affected dermatome, which is followed in 2-3 days by a vesicular eruption.

Famciclovir 500 mg or 750 mg three times daily for 7 days, is an effective and well-tolerated therapy for Herpes Zoster that decreases the duration of the disease’s most debilitating complication, PHN.

Genital herpes is a common sexually transmitted infection caused by the herpes simplex virus (HSV). Sexual contact is the primary way that the virus spreads. Genital herpes can cause pain, itching and sores in genital area.

Oral Famciclovir across all doses was found to be an effective and well tolerated in patients with Recurrent Genital Herpes and Varicella zoster virus infection (Chickenpox).

Single-day Famciclovir was like 3-day Valacyclovir in both efficacy and safety, representing a more convenient treatment for adults with Recurrent Genital Herpes.

Chickenpox, also known as varicella, is a highly contagious disease caused by the initial infection with varicella zoster virus (VZV). The disease results in a characteristic skin rash that forms small, itchy blisters, which eventually scab over. It usually starts on the chest, back, and face.

A single dose of Famciclovir offers a safe and effective alternative for patients with suspected / confirmed HSV and VZV infection.

Herpes labialis, commonly known as cold sores, is a type of infection by the herpes simplex virus that affects primarily the lip. Symptoms typically include a burning pain followed by small blisters or sores.

Famciclovir given twice a day is as effective and well tolerated as high-dose Acyclovir for mucocutaneous HSV infections in HIV infected individuals and has the convenience of less frequent dosing.

Recurrent herpes simplex labialis, also known as oral herpes, is an infection of the mouth area caused by the herpes simplex virus. These are commonly known as cold sores or fever blisters.

A single dose of Famciclovir offers a safe and effective alternative for patients with Recurrent Herpes Labialis.

Immunocompromised cancer patients are susceptible to infection by many viral pathogens. The development of infection remains a significant source of morbidity and mortality in the oncology patient.

Famciclovir results in clinically and statistically significant reductions in the symptoms associated with HSV infection and symptomatic and asymptomatic shedding of HSV among HIV-positive persons.

Bell's palsy causes sudden, temporary weakness in facial muscles. This makes half of face appear to droop. Smile is one-sided, and eye on that side resists closing. Bell's palsy, also known as facial palsy, can occur at any age.

Treatment with steroid + Famciclovir was more effective than treatment with steroid + acyclovir in patients with severe facial palsy. Famciclovir may be the antiviral agent of choice in the treatment of patients with severe facial palsy.

Eye herpes, also known as ocular herpes, is an infection of the eye by the herpes simplex virus (HSV). The most common type is called epithelial keratitis, and it affects the cornea, the clear front portion of eye. In its mild form, eye herpes causes: ... tearing of the cornea surface.

Famciclovir 500 mg three times daily demonstrated efficacy similar to Acyclovir 800 mg five times daily in the treatment of Ophthalmic Herpes Zoster but provides patients with a more convenient dosing regimen.

Herpes Zoster

Herpes zoster is viral infection that occurs with reactivation of the varicella-zoster virus. It is usually a painful but self-limited dermatomal rash. Symptoms typically start with pain along the affected dermatome, which is followed in 2-3 days by a vesicular eruption.

Famciclovir 500 mg or 750 mg three times daily for 7 days, is an effective and well-tolerated therapy for Herpes Zoster that decreases the duration of the disease’s most debilitating complication, PHN

Genital Herpes / Recurrent Genital Herpes

Genital herpes is a common sexually transmitted infection caused by the herpes simplex virus (HSV). Sexual contact is the primary way that the virus spreads. Genital herpes can cause pain, itching and sores in genital area.

Oral Famciclovir across all doses was found to be an effective and well tolerated in patients with Recurrent Genital Herpes and Varicella zoster virus infection (Chickenpox).

Single-day Famciclovir was like 3-day Valacyclovir in both efficacy and safety, representing a more convenient treatment for adults with Recurrent Genital Herpes.

Chickenpox

Chickenpox, also known as varicella, is a highly contagious disease caused by the initial infection with varicella zoster virus (VZV). The disease results in a characteristic skin rash that forms small, itchy blisters, which eventually scab over. It usually starts on the chest, back, and face.

A single dose of Famciclovir offers a safe and effective alternative for patients with suspected / confirmed HSV and VZV infection

Orolabial Herpes

Herpes labialis, commonly known as cold sores, is a type of infection by the herpes simplex virus that affects primarily the lip. Symptoms typically include a burning pain followed by small blisters or sores.

Famciclovir given twice a day is as effective and well tolerated as high-dose Acyclovir for mucocutaneous HSV infections in HIV infected individuals and has the convenience of less frequent dosing

Recurrent Herpes Labialis

Recurrent herpes simplex labialis, also known as oral herpes, is an infection of the mouth area caused by the herpes simplex virus. These are commonly known as cold sores or fever blisters.

A single dose of Famciclovir offers a safe and effective alternative for patients with Recurrent Herpes Labialis

Immunocompromised patients / Immunocompromised Cancer Patients

Immunocompromised cancer patients are susceptible to infection by many viral pathogens. The development of infection remains a significant source of morbidity and mortality in the oncology patient.

Famciclovir results in clinically and statistically significant reductions in the symptoms associated with HSV infection and symptomatic and asymptomatic shedding of HSV among HIV-positive persons

Bell’s Palsy

Bell's palsy causes sudden, temporary weakness in facial muscles. This makes half of face appear to droop. Smile is one-sided, and eye on that side resists closing. Bell's palsy, also known as facial palsy, can occur at any age.

Treatment with steroid + Famciclovir was more effective than treatment with steroid + acyclovir in patients with severe facial palsy. Famciclovir may be the antiviral agent of choice in the treatment of patients with severe facial palsy

Ocular Herpes

Eye herpes, also known as ocular herpes, is an infection of the eye by the herpes simplex virus (HSV). The most common type is called epithelial keratitis, and it affects the cornea, the clear front portion of eye. In its mild form, eye herpes causes: ... tearing of the cornea surface.

Famciclovir 500 mg three times daily demonstrated efficacy similar to Acyclovir 800 mg five times daily in the treatment of Ophthalmic Herpes Zoster but provides patients with a more convenient dosing regimen.

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Interaction with Alcohol

Alcohol intolerance can cause reactions like stuffy nose and skin flushing. Penvir helps in the treatment of clearing the antiviral infection.

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Food interactions

A Food allergy occurs when your immune system overreacts to a food and trigger allergic reactions like itching in the mouth, hives, swelling of the lips, face etc. Penvir is an antiviral drug, helps to fight off the infection.

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Disease interactions

Penvir is an antiviral drug treats shingles caused by herpes zoster, which occurs in patients who have had chickenpox in the past and used to treats infections caused by various types of viruses.

post-1
Alcohol intolerance can cause reactions like stuffy nose and skin flushing. Penvir helps in the treatment of clearing the antiviral infection.
Interaction with Alcohol
post-1
A Food allergy occurs when your immune system overreacts to a food and trigger allergic reactions like itching in the mouth, hives, swelling of the lips, face etc. Penvir is an antiviral drug, helps to fight off the infection.
Food interactions
post-1
Penvir is an antiviral drug treats shingles caused by herpes zoster, which occurs in patients who have had chickenpox in the past and used to treats infections caused by various types of viruses.
Disease interactions

Product

About Penvir

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PENVIR belongs to the anti-viral product range offered by KRIS and is available as PENVIR 250 mg and PENVIR 500 mg tablets.
PENVIR contains Famciclovir, which is a prodrug of Penciclovir with highly selective antiviral action.
PENVIR is currently approved worldwide for the treatment of VZV, HSV-1 and HSV-2 infections.

Characteristics of Famciclovir

  • High Bioavailability
  • Prolonged Intracellular Half-life
  • High Selectivity for Viral DNA
  • Suitable in Patients with Renal Toxicity
  • Convenient TID Dosage Regimen
  • Documented evidence in Post Herpetic Neuralgia (PHN)
  • Less Pharmacokinetic Interactions
  • Good Duodenal Stability
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Testimonials

What People Say?

Frequently Asked Questions

With PENVIR (Famciclovir) dosage therapy is quite convenient for patients compared to Aciclovir

  • Herpes Zoster (shingles): 500 mg every 8 hours for 7 days
  • Herpes Labialis (cold sores): 1500 mg as a single dose
  • Genital Herpes
    • First episode: 250 mg TID for 7-10 days
    • Suppressive therapy: 250 mg twice daily
    • Treatment of recurrent episodes: 1000 mg twice daily for 1 day
  • Chickenpox
    • Adult - 500 mg TID for 7-10 days
    • Children below 40 kg: 12.5 mg / kg/ dose TID for
  • Bell’s Palsy: 250 mg TID for 5-7 days
  • Ocular Herpes: 500 mg TID for 7 days
  • Laryngo Pharyngeal Palsy: 500 mg TIS for 1 month

PENVIR (Famciclovir) is safe and can be given even in 1st trimester of pregnancy with no abnormalities reported.

No issue as the intracellular half-life of is PENVIR (Famciclovir) is up to 19 hours. Need to take medicine as soon as remember it.

Unless you are allergic to Famciclovir, PENVIR (Famciclovir) has no major side-effects. It can be given to renal failure patients or immune-compromised patients also.

PENVIR (Famciclovir) is available at major retailers. For more details download App (Penvir We Care For You) and locate nearby chemist.

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To order or to know more details about Penvir, reach us by filling the form. we will get back you within 1-2 business days.

Corporate Office

Hetero Healthcare Limited

Sy.No 80-84, Melange Towers,

4th Floor, C Wing, Patrika Nagar,

Madhapur, Hyderabad, Telangana

500081, India.

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Marketing Office

Hetero Healthcare Limited

A-202/B201, Dipit Classic,

32/34, W.T.Suren Road,

Andheri(East), Mumbai, Maharashtra

400093, India.

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lead@heterohealthcare.com

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Office : 040 4047 35 35

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